Reaction Details Report a problem with these data
Target
NADH-ubiquinone oxidoreductase chain 1
Ligand
BDBM50488012
Substrate
n/a
Meas. Tech.
ChEMBL_918170 (CHEMBL3060412)
IC50
530±n/a nM
Citation
 Yabunaka, H; Kenmochi, A; Nakatogawa, Y; Sakamoto, K; Miyoshi, H Hybrid ubiquinone: novel inhibitor of mitochondrial complex I. Biochim Biophys Acta 1556:106-12 (2002) [PubMed]  Article 
Target
Name:
NADH-ubiquinone oxidoreductase chain 1
Synonyms:
MT-ND1 | MTND1 | NADH Oxidase | NADH-ubiquinone oxidoreductase | NADH-ubiquinone oxidoreductase chain 1 | NADH1 | ND1 | NU1M_BOVIN
Type:
Protein
Mol. Mass.:
35672.63
Organism:
Bos taurus (Bovine)
Description:
P03887
Residue:
318
Sequence:
MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT
  
Inhibitor
Name:
BDBM50488012
Synonyms:
CHEMBL2272023
Type:
Small organic molecule
Emp. Form.:
C27H29NO6
Mol. Mass.:
463.5223
SMILES:
COC1=C(OC)C(=O)C(CNC(=O)c2ccc(Oc3ccc(cc3)C(C)(C)C)cc2)=C(C)C1=O |c:2,t:31|
Structure:
Search PDB for entries with ligand similarity: