Reaction Details Report a problem with these data
Target
NADH-ubiquinone oxidoreductase chain 1
Ligand
BDBM50488013
Substrate
n/a
Meas. Tech.
ChEMBL_918171 (CHEMBL3060413)
IC50
1800±n/a nM
Citation
 Yabunaka, H; Kenmochi, A; Nakatogawa, Y; Sakamoto, K; Miyoshi, H Hybrid ubiquinone: novel inhibitor of mitochondrial complex I. Biochim Biophys Acta 1556:106-12 (2002) [PubMed]  Article 
Target
Name:
NADH-ubiquinone oxidoreductase chain 1
Synonyms:
MT-ND1 | MTND1 | NADH Oxidase | NADH-ubiquinone oxidoreductase | NADH-ubiquinone oxidoreductase chain 1 | NADH1 | ND1 | NU1M_BOVIN
Type:
Protein
Mol. Mass.:
35672.63
Organism:
Bos taurus (Bovine)
Description:
P03887
Residue:
318
Sequence:
MFMINILMLIIPILLAVAFLTLVERKVLGYMQLRKGPNVVGPYGLLQPIADAIKLFIKEPLRPATSSASMFILAPIMALGLALTMWIPLPMPYPLINMNLGVLFMLAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSVLLMSGSFTLSTLITTQEQMWLILPAWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYANIIMMNIFTAILFLGTSHNPHMPELYTINFTIKSLLLTMSFLWIRASYPRFRYDQLMHLLWKNFLPLTLALCMWHVSLPILTSGIPPQT
  
Inhibitor
Name:
BDBM50488013
Synonyms:
CHEMBL2272024
Type:
Small organic molecule
Emp. Form.:
C28H31NO6
Mol. Mass.:
477.5488
SMILES:
COC1=C(OC)C(=O)C(CC(=O)N(C)c2ccc(Oc3ccc(cc3)C(C)(C)C)cc2)=C(C)C1=O |c:2,t:32|
Structure:
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