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Target
Sterol O-acyltransferase 1
Ligand
BDBM50034734
Substrate
n/a
Meas. Tech.
ChEMBL_28793 (CHEMBL641703)
IC50
2300±n/a nM
Citation
 Clader, JW; Berger, JG; Burrier, RE; Davis, HR; Domalski, M; Dugar, S; Kogan, TP; Salisbury, B; Vaccaro, W Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity. J Med Chem 38:1600-7 (1995) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50034734
Synonyms:
2,2-Diphenyl-N-(2-phenyl-1-pyridin-4-yl-ethyl)-acetamide | CHEMBL38881
Type:
Small organic molecule
Emp. Form.:
C27H24N2O
Mol. Mass.:
392.4923
SMILES:
O=C(NC(Cc1ccccc1)c1ccncc1)C(c1ccccc1)c1ccccc1
Structure:
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