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Target
Translocator protein
Ligand
BDBM50491004
Substrate
n/a
Meas. Tech.
ChEMBL_957539 (CHEMBL2378342)
Ki
0.350000±n/a nM
Citation
O'Shea, D; Ahmad, R; Årstad, E; Avory, M; Chau, WF; Durrant, C; Hirani, E; Jones, PA; Khan, I; Luthra, SK; Mantzilas, D; Morisson-Iveson, V; Passmore, J; Robins, EG; Shan, B; Wadsworth, H; Walton, S; Zhao, Y; Trigg, W Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents. Bioorg Med Chem Lett 23:2368-72 (2013) [PubMed] Article
More Info.:
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE