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Target
Macrophage migration inhibitory factor
Ligand
BDBM50491189
Substrate
n/a
Meas. Tech.
ChEMBL_957350 (CHEMBL2377973)
Kd
35900±n/a nM
Citation
 Yu, WL; Jones, BD; Kang, M; Hammons, JC; La Clair, JJ; Burkart, MD Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF). J Nat Prod 76:817-23 (2013) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50491189
Synonyms:
CHEMBL2375653
Type:
Small organic molecule
Emp. Form.:
C25H28O5
Mol. Mass.:
408.4868
SMILES:
C[C@H]1C[C@@]23OC(=O)\C(C2=O)=C2\OC\C(\C=C2)=C/[C@H](O)C\C=C\C(\C)=C\[C@@]3(C)C=C1C |r,c:15,17,30,t:10,22,25|
Structure:
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