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Target
Histamine H4 receptor
Ligand
BDBM50491218
Substrate
n/a
Meas. Tech.
ChEMBL_957492 (CHEMBL2378230)
Ki
50±n/a nM
Citation
 Engelhardt, H; Schultes, S; de Graaf, C; Nijmeijer, S; Vischer, HF; Zuiderveld, OP; Dobler, J; Stachurski, K; Mayer, M; Arnhof, H; Scharn, D; Haaksma, EE; de Esch, IJ; Leurs, R Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode. J Med Chem 56:4264-76 (2013) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50491218
Synonyms:
CHEMBL2375771
Type:
Small organic molecule
Emp. Form.:
C21H27ClN8
Mol. Mass.:
426.946
SMILES:
CC(C)CNc1nccc(NCCN(C)c2cc(nc(N)n2)-c2cccc(Cl)c2)n1
Structure:
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