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Target
RNA-directed RNA polymerase
Ligand
BDBM50491701
Substrate
n/a
Meas. Tech.
ChEMBL_962074 (CHEMBL2388191)
IC50
2800±n/a nM
Citation
 Patel, BA; Krishnan, R; Khadtare, N; Gurukumar, KR; Basu, A; Arora, P; Bhatt, A; Patel, MR; Dana, D; Kumar, S; Kaushik-Basu, N; Talele, TT Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase. Bioorg Med Chem 21:3262-71 (2013) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
2.7.7.48 | NS5b | RNA-directed RNA polymerase
Type:
PROTEIN
Mol. Mass.:
65779.30
Organism:
Hepacivirus C
Description:
ChEMBL_118447
Residue:
591
Sequence:
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIRSVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
  
Inhibitor
Name:
BDBM50491701
Synonyms:
CHEMBL2387643
Type:
Small organic molecule
Emp. Form.:
C25H17Cl2NO4S2
Mol. Mass.:
530.443
SMILES:
OC(=O)[C@H](Cc1ccccc1)N1C(=S)S\C(=C/c2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C1=O |r|
Structure:
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