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Target
Integrase
Ligand
BDBM50492369
Substrate
n/a
Meas. Tech.
ChEMBL_972010 (CHEMBL2405961)
IC50
48±n/a nM
Citation
 Okello, M; Mishra, S; Nishonov, M; Nair, V Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations. Bioorg Med Chem Lett 23:4112-6 (2013) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50492369
Synonyms:
CHEMBL2401912
Type:
Small organic molecule
Emp. Form.:
C28H25F3N2O5
Mol. Mass.:
526.5037
SMILES:
O[C@@H]1CCC[C@H]1NC(=O)C(=O)\C=C(/O)c1cc(Cc2ccc(F)cc2F)cn(Cc2ccccc2F)c1=O |r|
Structure:
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