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Target
Kappa-type opioid receptor
Ligand
BDBM50037580
Substrate
n/a
Meas. Tech.
ChEMBL_145564 (CHEMBL752653)
Ki
52.1±n/a nM
Citation
 Giardina, G; Clarke, GD; Dondio, G; Petrone, G; Sbacchi, M; Vecchietti, V Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group. J Med Chem 37:3482-91 (1994) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1
Type:
Enzyme
Mol. Mass.:
42656.78
Organism:
Mus musculus (Mouse)
Description:
P33534
Residue:
380
Sequence:
MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
  
Inhibitor
Name:
BDBM50037580
Synonyms:
6-(2-{(S)-2-[(Cyclopropyl-methyl-amino)-methyl]-piperidin-1-yl}-2-oxo-ethyl)-3,4-dihydro-2H-naphthalen-1-one | CHEMBL324119
Type:
Small organic molecule
Emp. Form.:
C22H30N2O2
Mol. Mass.:
354.4858
SMILES:
CN(C[C@@H]1CCCCN1C(=O)Cc1ccc2C(=O)CCCc2c1)C1CC1
Structure:
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