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Target
Kappa-type opioid receptor
Ligand
BDBM50492488
Substrate
n/a
Meas. Tech.
ChEMBL_969752 (CHEMBL2404094)
Ki
>500±n/a nM
Citation
 Touati-Jallabe, Y; Bojnik, E; Legrand, B; Mauchauffée, E; Chung, NN; Schiller, PW; Benyhe, S; Averlant-Petit, MC; Martinez, J; Hernandez, JF Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations. J Med Chem 56:5964-5973 (2013) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50492488
Synonyms:
CHEMBL2402929
Type:
Small organic molecule
Emp. Form.:
C31H41N9O6
Mol. Mass.:
635.7139
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CN\C(=N/C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O)C(N)=O)N1CCCC1 |r,c:17|
Structure:
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