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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038909
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
28.7±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038909
Synonyms:
1-(6-Chloro-4-o-tolyl-quinolin-3-yl)-3-(2,4-difluoro-phenyl)-urea | CHEMBL63593
Type:
Small organic molecule
Emp. Form.:
C23H16ClF2N3O
Mol. Mass.:
423.842
SMILES:
Cc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12 |(4.13,-9.36,;5.46,-10.13,;5.46,-11.67,;6.8,-12.44,;8.13,-11.65,;8.14,-10.13,;6.8,-9.36,;6.8,-7.82,;8.13,-7.05,;9.46,-7.82,;10.79,-7.05,;10.78,-5.51,;12.13,-7.8,;12.14,-9.34,;10.81,-10.11,;10.81,-11.65,;12.16,-12.42,;12.16,-13.96,;13.49,-11.63,;13.47,-10.1,;14.8,-9.32,;8.12,-5.51,;6.77,-4.74,;5.46,-5.51,;4.11,-4.74,;2.78,-5.53,;2.78,-7.07,;1.45,-7.82,;4.13,-7.82,;5.46,-7.05,)|
Structure:
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