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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038908
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
125±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038908
Synonyms:
1-[4-(2-Chloro-phenyl)-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL65347
Type:
Small organic molecule
Emp. Form.:
C22H14ClF2N3O
Mol. Mass.:
409.816
SMILES:
Fc1ccc(NC(=O)Nc2cnc3ccccc3c2-c2ccccc2Cl)c(F)c1 |(8.52,-13.45,;8.52,-11.91,;7.17,-11.15,;7.17,-9.61,;8.5,-8.84,;8.49,-7.3,;7.15,-6.54,;7.15,-5,;5.82,-7.31,;4.49,-6.54,;4.48,-5,;3.13,-4.23,;1.82,-5.02,;.47,-4.25,;-.86,-5.02,;-.86,-6.56,;.49,-7.31,;1.82,-6.56,;3.16,-7.33,;3.16,-8.87,;4.5,-9.62,;4.49,-11.15,;3.16,-11.93,;1.82,-11.16,;1.82,-9.62,;.49,-8.85,;9.83,-9.6,;11.16,-8.8,;9.85,-11.13,)|
Structure:
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