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Target
Carbonic anhydrase 12
Ligand
BDBM150256
Substrate
n/a
Meas. Tech.
ChEMBL_1276464 (CHEMBL3088560)
Ki
6.7±n/a nM
Citation
 Rami, M; Dubois, L; Parvathaneni, NK; Alterio, V; van Kuijk, SJ; Monti, SM; Lambin, P; De Simone, G; Supuran, CT; Winum, JY Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates. J Med Chem 56:8512-20 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM150256
Synonyms:
US8980932, 4c (DH305)
Type:
Small organic molecule
Emp. Form.:
C13H15N5O5S
Mol. Mass.:
353.354
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)Cn2ccnc2[N+]([O-])=O)cc1
Structure:
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