Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50495165
Substrate
n/a
Meas. Tech.
ChEMBL_1284657 (CHEMBL3107238)
IC50
510±n/a nM
Citation
 Porter, DW; Bradley, M; Brown, Z; Canova, R; Charlton, S; Cox, B; Hunt, P; Kolarik, D; Lewis, S; O'Connor, D; Reilly, J; Spanka, C; Tedaldi, L; Watson, SJ; Wermuth, R; Press, NJ The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists. Bioorg Med Chem Lett 24:72-6 (2014) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50495165
Synonyms:
CHEMBL3105077
Type:
Small organic molecule
Emp. Form.:
C18H18F2N4OS
Mol. Mass.:
376.424
SMILES:
Oc1cc(CSc2cccc(F)c2F)nc2nc(nn12)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: