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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50042099
Substrate
n/a
Meas. Tech.
ChEBML_28188
IC50
470±n/a nM
Citation
 Trivedi, BK; Holmes, A; Stoeber, TL; Blankley, CJ; Roark, WH; Picard, JA; Shaw, MK; Essenburg, AD; Stanfield, RL; Krause, BR Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents. J Med Chem 36:3300-7 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50042099
Synonyms:
1-(2,5-Dimethyl-phenyl)-3-(1-phenyl-cyclohexylmethyl)-urea | CHEMBL112738
Type:
Small organic molecule
Emp. Form.:
C22H28N2O
Mol. Mass.:
336.4705
SMILES:
Cc1ccc(C)c(NC(=O)NCC2(CCCCC2)c2ccccc2)c1
Structure:
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