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Target
Thymidine phosphorylase
Ligand
BDBM50495299
Substrate
n/a
Meas. Tech.
ChEMBL_1283725 (CHEMBL3108305)
IC50
88730±n/a nM
Citation
 Shahzad, SA; Yar, M; Bajda, M; Jadoon, B; Khan, ZA; Naqvi, SA; Shaikh, AJ; Hayat, K; Mahmmod, A; Mahmood, N; Filipek, S Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents. Bioorg Med Chem 22:1008-15 (2014) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50495299
Synonyms:
CHEMBL3103318
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O2S
Mol. Mass.:
347.819
SMILES:
COc1ccccc1NCn1nc(oc1=S)-c1ccc(Cl)cc1
Structure:
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