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Target
Type-1 angiotensin II receptor
Ligand
BDBM50042538
Substrate
n/a
Meas. Tech.
ChEBML_36933
IC50
0.520000±n/a nM
Citation
 Ashton, WT; Hutchins, SM; Greenlee, WJ; Doss, GA; Chang, RS; Lotti, VJ; Faust, KA; Chen, TB; Zingaro, GJ; Kivlighn, SD Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates. J Med Chem 36:3595-605 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50042538
Synonyms:
5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2,2,2-trifluoro-ethyl)-2H-pyrazole-3-carboxylic acid | CHEMBL281386
Type:
Small organic molecule
Emp. Form.:
C24H23F3N6O2
Mol. Mass.:
484.4736
SMILES:
CCCCc1nn(CC(F)(F)F)c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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