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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50005347
Substrate
n/a
Meas. Tech.
ChEMBL_34819 (CHEMBL648963)
IC50
400±n/a nM
Citation
 Ries, UJ; Mihm, G; Narr, B; Hasselbach, KM; Wittneben, H; Entzeroth, M; van Meel, JC; Wienen, W; Hauel, NH 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J Med Chem 36:4040-51 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50005347
Synonyms:
4'-((2-butyl-1H-benzo[d]imidazol-1-yl)methyl)biphenyl-2-carboxylic acid | 4'-(2-Butyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid | 4'-(2-Butyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid;0.25H2O | CHEMBL7632
Type:
Small organic molecule
Emp. Form.:
C25H24N2O2
Mol. Mass.:
384.4703
SMILES:
CCCCc1nc2ccccc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Structure:
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