Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50043434
Substrate
n/a
Meas. Tech.
ChEMBL_35406 (CHEMBL647505)
IC50
>30000±n/a nM
Citation
Dhanoa, DS; Bagley, SW; Chang, RS; Lotti, VJ; Chen, TB; Kivlighn, SD; Zingaro, GJ; Siegl, PK; Patchett, AA; Greenlee, WJ Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. J Med Chem 36:4230-8 (1994) [PubMed] Article
More Info.:
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
Inhibitor
Name:
BDBM50043434
Synonyms:
2-Ethyl-5,7-dimethyl-4-{1-[phenyl-(1H-tetrazol-5-yl)-methyl]-2,3-dihydro-1H-indol-5-ylmethyl}-3H-imidazo[4,5-b]pyridine | CHEMBL442963
Type:
Small organic molecule
Emp. Form.:
C27H28N8
Mol. Mass.:
464.5648
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc2N(CCc2c1)C(c1nnn[nH]1)c1ccccc1