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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50010754
Substrate
n/a
Meas. Tech.
ChEMBL_201739 (CHEMBL803935)
IC50
242±n/a nM
Citation
 Reddy, NL; Hu, LY; Cotter, RE; Fischer, JB; Wong, WJ; McBurney, RN; Weber, E; Holmes, DL; Wong, ST; Prasad, R Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J Med Chem 37:260-7 (1994) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50010754
Synonyms:
CHEMBL81626 | N,N'-Bis-(4-isopropyl-phenyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C19H25N3
Mol. Mass.:
295.4219
SMILES:
CC(C)c1ccc(NC(N)=Nc2ccc(cc2)C(C)C)cc1 |w:10.10|
Structure:
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