Reaction Details Report a problem with these data
Target
Methionine aminopeptidase
Ligand
BDBM50497528
Substrate
n/a
Meas. Tech.
ChEMBL_1437717 (CHEMBL3382364)
IC50
7800±n/a nM
Citation
 Altmeyer, M; Amtmann, E; Heyl, C; Marschner, A; Scheidig, AJ; Klein, CD Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg Med Chem Lett 24:5310-4 (2014) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
MAP1_STAAW | MetAP | Methionine Aminopeptidase (MAP) | Peptidase M | SaMetAP-1 | map
Type:
Enzyme
Mol. Mass.:
27494.40
Organism:
Staphylococcus aureus
Description:
P0A079
Residue:
252
Sequence:
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
  
Inhibitor
Name:
BDBM50497528
Synonyms:
CHEMBL3337742
Type:
Small organic molecule
Emp. Form.:
C12H15BrClNO
Mol. Mass.:
304.611
SMILES:
Cl.CN(C)CC1Cc2cc(Br)ccc2C1=O
Structure:
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