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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50045912
Substrate
n/a
Meas. Tech.
ChEBML_28349
IC50
>1000±n/a nM
Citation
 Augelli-Szafran, CE; Blankley, CJ; Roth, BD; Trivedi, BK; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents. J Med Chem 36:2943-9 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50045912
Synonyms:
2,2-Dimethyl-3-oxo-tetradecanoic acid methyl-(2,4,6-trimethoxy-phenyl)-amide | CHEMBL98377
Type:
Small organic molecule
Emp. Form.:
C26H43NO5
Mol. Mass.:
449.6233
SMILES:
CCCCCCCCCCCC(=O)C(C)(C)C(=O)N(C)c1c(OC)cc(OC)cc1OC
Structure:
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