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Target
Cytosol aminopeptidase
Ligand
BDBM50046329
Substrate
n/a
Meas. Tech.
ChEBML_98531
IC50
50000±n/a nM
Citation
 Yuan, W; Munoz, B; Wong, CH; Haeggström, JZ; Wetterholm, A; Samuelsson, B Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. J Med Chem 36:211-20 (1993) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_HUMAN | Aminopeptidase | LAP3 | LAPEP | Leucine aminopeptidase | PEPS
Type:
PROTEIN
Mol. Mass.:
56171.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507539
Residue:
519
Sequence:
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
  
Inhibitor
Name:
BDBM50046329
Synonyms:
3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester | CHEMBL68679
Type:
Small organic molecule
Emp. Form.:
C18H19NO4
Mol. Mass.:
313.3478
SMILES:
COC(=O)C(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1
Structure:
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