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Target
Histone acetyltransferase KAT8
Ligand
BDBM50240436
Substrate
n/a
Meas. Tech.
ChEMBL_1537913 (CHEMBL3738205)
IC50
213796208950±n/a nM
Citation
 Wapenaar, H; van der Wouden, PE; Groves, MR; Rotili, D; Mai, A; Dekker, FJ Enzyme kinetics and inhibition of histone acetyltransferase KAT8. Eur J Med Chem 105:289-96 (2015) [PubMed]  Article 
Target
Name:
Histone acetyltransferase KAT8
Synonyms:
KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF
Type:
PROTEIN
Mol. Mass.:
52413.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796800
Residue:
458
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
  
Inhibitor
Name:
BDBM50240436
Synonyms:
2-Hydroxy-6-pentadecyl-benzoic acid | 2-hydroxy-6-pentadecylbenzoic acid | 6-(pentadecenyl)salicylic acid | anacardic acid
Type:
Small organic molecule
Emp. Form.:
C22H36O3
Mol. Mass.:
348.5194
SMILES:
CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
Structure:
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