Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50500024
Substrate
n/a
Meas. Tech.
ChEMBL_1541745 (CHEMBL3745427)
Ki
2.9±n/a nM
Citation
 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds. Bioorg Med Chem 24:20-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50500024
Synonyms:
CHEMBL3740966
Type:
Small organic molecule
Emp. Form.:
C18H13NO8
Mol. Mass.:
371.2977
SMILES:
COc1cc(NC(=O)c2ccc3C(=O)OC(=O)c3c2)c(cc1OC)C(O)=O
Structure:
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