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Target
CAAX prenyl protease 2
Ligand
BDBM50500093
Substrate
n/a
Meas. Tech.
ChEMBL_1541784 (CHEMBL3742598)
IC50
11000±n/a nM
Citation
 Mohammed, I; Hampton, SE; Ashall, L; Hildebrandt, ER; Kutlik, RA; Manandhar, SP; Floyd, BJ; Smith, HE; Dozier, JK; Distefano, MD; Schmidt, WK; Dore, TM 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem 24:160-78 (2016) [PubMed]  Article 
Target
Name:
CAAX prenyl protease 2
Synonyms:
CAAX prenyl protease 2 | FACE-2 | FACE2 | FACE2_HUMAN | Farnesylated proteins-converting enzyme 2 | Prenyl protein specific protease | Prenyl protein-specific endoprotease 2 | RCE1 | RCE1 homolog | RCE1A | RCE1B | hRCE1
Type:
PROTEIN
Mol. Mass.:
35839.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_194935
Residue:
329
Sequence:
MAALGGDGLRLLSVSRPERPPESAALGGLGPGLCCWVSVFSCLSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCMGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERAGDSEAPLCS
  
Inhibitor
Name:
BDBM50500093
Synonyms:
CHEMBL2006267
Type:
Small organic molecule
Emp. Form.:
C22H17N3O3
Mol. Mass.:
371.3887
SMILES:
Oc1c(ccc2cccnc12)C(Nc1ccccc1)c1ccc(cc1)[N+]([O-])=O
Structure:
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