Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM50052614
Substrate
n/a
Meas. Tech.
ChEMBL_212401 (CHEMBL815988)
IC50
150000±n/a nM
Citation
 Muller, GW; Corral, LG; Shire, MG; Wang, H; Moreira, A; Kaplan, G; Stirling, DI Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. J Med Chem 39:3238-40 (1996) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM50052614
Synonyms:
3-(4-Cyano-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide | CHEMBL110972
Type:
Small organic molecule
Emp. Form.:
C18H13N3O3
Mol. Mass.:
319.3141
SMILES:
NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(cc1)C#N
Structure:
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