Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50052963
Substrate
n/a
Meas. Tech.
ChEMBL_201430 (CHEMBL809833)
Ki
5460±n/a nM
Citation
 Zhang, Y; Williams, W; Bowen, WD; Rice, KC Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity. J Med Chem 39:3564-8 (1996) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50052963
Synonyms:
2-(2-Methoxy-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-ethyl)-acetamide | CHEMBL117051
Type:
Small organic molecule
Emp. Form.:
C16H24N2O2
Mol. Mass.:
276.374
SMILES:
COc1ccccc1CC(=O)N(C)CCN1CCCC1
Structure:
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