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Target
Reduced folate transporter
Ligand
BDBM50457435
Substrate
n/a
Meas. Tech.
ChEMBL_1809828 (CHEMBL4309288)
IC50
634±n/a nM
Citation
 Ravindra, M; Wilson, MR; Tong, N; O'Connor, C; Karim, M; Polin, L; Wallace-Povirk, A; White, K; Kushner, J; Hou, Z; Matherly, LH; Gangjee, A Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem 61:4228-4248 (2018) [PubMed]  Article 
Target
Name:
Reduced folate transporter
Synonyms:
FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1
Type:
PROTEIN
Mol. Mass.:
64885.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469594
Residue:
591
Sequence:
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
  
Inhibitor
Name:
BDBM50457435
Synonyms:
CHEMBL4214638
Type:
Small organic molecule
Emp. Form.:
C21H24N6O6
Mol. Mass.:
456.4519
SMILES:
Nc1nc2[nH]c(CCCCc3ccc(nc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r|
Structure:
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