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Target
Calpain-2 catalytic subunit
Ligand
BDBM50503847
Substrate
n/a
Meas. Tech.
ChEMBL_1812367 (CHEMBL4311827)
IC50
34±n/a nM
Citation
 Pehere, AD; Nguyen, S; Garlick, SK; Wilson, DW; Hudson, I; Sykes, MJ; Morton, JD; Abell, AD Tripeptide analogues of MG132 as protease inhibitors. Bioorg Med Chem 27:436-441 (2019) [PubMed]  Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain
Type:
n/a
Mol. Mass.:
37789.71
Organism:
Sus scrofa
Description:
n/a
Residue:
324
Sequence:
YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRISKQLDSENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50503847
Synonyms:
CHEMBL4574306
Type:
Small organic molecule
Emp. Form.:
C35H39N3O6
Mol. Mass.:
597.7007
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccc(OCC#C)cc1)C=O |r|
Structure:
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