Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50504053
Substrate
n/a
Meas. Tech.
ChEMBL_1813254 (CHEMBL4312828)
Ki
5150±n/a nM
Citation
 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F Mechanistic Insight on the Mode of Action of Colletoic Acid. J Med Chem 62:6925-6940 (2019) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50504053
Synonyms:
CHEMBL4536375
Type:
Small organic molecule
Emp. Form.:
C15H22O3
Mol. Mass.:
250.3334
SMILES:
CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)C(=O)C1 |r,t:13|
Structure:
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