Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50504188
Substrate
n/a
Meas. Tech.
ChEMBL_1813996 (CHEMBL4313570)
Ki
369±n/a nM
Citation
 Romeo, G; Salerno, L; Pittalą, V; Candido, M; Intagliata, S; Amata, E; Salmona, M; Cagnotto, A; Rescifina, A; Floresta, G; Modica, MN [1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50504188
Synonyms:
CHEMBL4475894
Type:
Small organic molecule
Emp. Form.:
C23H24N4OS2
Mol. Mass.:
436.593
SMILES:
O=c1[nH]c(SCCCN2CCN(CC2)c2ccccc2)nc2c3ccccc3sc12
Structure:
Search PDB for entries with ligand similarity: