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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50504225
Substrate
n/a
Meas. Tech.
ChEMBL_1814066 (CHEMBL4313640)
Ki
1400±n/a nM
Citation
 Klejch, T; Keough, DT; Chavchich, M; Travis, J; Skácel, J; Pohl, R; Janeba, Z; Edstein, MD; Avery, VM; Guddat, LW; Hocková, D Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50504225
Synonyms:
CHEMBL4546549
Type:
Small organic molecule
Emp. Form.:
C9H12N5Na2O4PS
Mol. Mass.:
363.241
SMILES:
n/a
Structure:
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