Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50504391
Substrate
n/a
Meas. Tech.
ChEMBL_1814623 (CHEMBL4314197)
Ki
1023±n/a nM
Citation
 Chen, P; Zhang, D; Li, M; Wu, Q; Lam, YPY; Guo, Y; Chen, C; Bai, N; Malhotra, S; Li, W; O'Connor, PB; Fu, H Discovery of novel, potent, isosteviol-based antithrombotic agents. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50504391
Synonyms:
CHEMBL4582546
Type:
Small organic molecule
Emp. Form.:
C30H40F3NO4
Mol. Mass.:
535.6381
SMILES:
[H][C@@]12CC[C@@]3(C)C[C@@]1(C\C3=N/OCc1ccc(OC(F)(F)F)cc1)CC[C@]1([H])[C@@](C)(CCC[C@@]21C)C(=O)OCC |r,THB:10:9:6:1.3.2|
Structure:
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