Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50055114
Substrate
n/a
Meas. Tech.
ChEMBL_195328 (CHEMBL857604)
Kd
129±n/a nM
Citation
 Johnson, AT; Klein, ES; Wang, L; Pino, ME; Chandraratna, RA Identification of retinoic acid receptor beta subtype specific agonists. J Med Chem 39:5027-30 (1997) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50055114
Synonyms:
4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthalen-2-ylethynyl)-benzoic acid | CHEMBL147937
Type:
Small organic molecule
Emp. Form.:
C25H20O2S
Mol. Mass.:
384.49
SMILES:
CC1(C)CC=C(c2cccs2)c2cc(ccc12)C#Cc1ccc(cc1)C(O)=O |t:4|
Structure:
Search PDB for entries with ligand similarity: