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Target
Geranylgeranyl transferase type-2 subunit alpha/beta
Ligand
BDBM50504715
Substrate
n/a
Meas. Tech.
ChEMBL_1816325 (CHEMBL4315899)
IC50
810000±n/a nM
Citation
 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA Novel benzimidazole phosphonates as potential inhibitors of protein prenylation. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-2 subunit alpha/beta
Synonyms:
Geranylgeranyl transferase type-2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1816325
Components:
This complex has 2 components.
Component 1
Name:
Geranylgeranyl transferase type-2 subunit beta
Synonyms:
2.5.1.60 | GGTase-II-beta | Geranylgeranyl transferase type II subunit beta | Geranylgeranyl transferase type-2 subunit beta | Ggtb | PGTB2_RAT | Rab GG transferase beta | Rab GGTase beta | Rab geranyl-geranyltransferase subunit beta | Rab geranylgeranyltransferase subunit beta | Rabggtb | Type II protein geranyl-geranyltransferase subunit beta
Type:
PROTEIN
Mol. Mass.:
36843.77
Organism:
Rattus norvegicus
Description:
ChEMBL_119712
Residue:
331
Sequence:
MGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS
  
Component 2
Name:
Geranylgeranyl transferase type-2 subunit alpha
Synonyms:
2.5.1.60 | Geranylgeranyl transferase type II subunit alpha | Geranylgeranyl transferase type-2 subunit alpha | Ggta | PGTA_RAT | Rab GG transferase alpha | Rab GGTase alpha | Rab geranyl-geranyltransferase subunit alpha | Rab geranylgeranyltransferase subunit alpha | Rabggta
Type:
PROTEIN
Mol. Mass.:
64893.04
Organism:
Rattus norvegicus
Description:
ChEMBL_119712
Residue:
567
Sequence:
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT
  
Inhibitor
Name:
BDBM50504715
Synonyms:
CHEMBL4514446
Type:
Small organic molecule
Emp. Form.:
C11H13N2O5P
Mol. Mass.:
284.2051
SMILES:
CC(Cn1cnc2ccccc12)(C(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: