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Target
Integrase
Ligand
BDBM50055686
Substrate
n/a
Meas. Tech.
ChEMBL_88614 (CHEMBL701718)
IC50
22500±n/a nM
Citation
 Zhao, H; Neamati, N; Hong, H; Mazumder, A; Wang, S; Sunder, S; Milne, GW; Pommier, Y; Burke, TR Coumarin-based inhibitors of HIV integrase. J Med Chem 40:242-9 (1997) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50055686
Synonyms:
7-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-7H-pyrano[3,2-c;5,6-c']dichromene-6,8-dione | CHEMBL82742
Type:
Small organic molecule
Emp. Form.:
C28H14O8
Mol. Mass.:
478.406
SMILES:
Oc1c(C2c3c(Oc4c2c(=O)oc2ccccc42)c2ccccc2oc3=O)c(=O)oc2ccccc12
Structure:
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