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Target
Carbonic anhydrase 6
Ligand
BDBM50504914
Substrate
n/a
Meas. Tech.
ChEMBL_1816904 (CHEMBL4316478)
Kd
1300±n/a nM
Citation
 Zak?auskas, A; ?apkauskait?, E; Jezep?ikas, L; Linkuvien?, V; Paketuryt?, V; Smirnov, A; Leitans, J; Kazaks, A; Dvinskis, E; Manakova, E; Gra?ulis, S; Tars, K; Matulis, D Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM50504914
Synonyms:
CHEMBL4558287
Type:
Small organic molecule
Emp. Form.:
C16H23ClN2O6S2
Mol. Mass.:
438.947
SMILES:
NS(=O)(=O)c1cc(C(=O)NCCCO)c(cc1Cl)S(=O)(=O)C1CCCCC1
Structure:
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