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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50052767
Substrate
n/a
Meas. Tech.
ChEMBL_1821756 (CHEMBL4321416)
IC50
650±n/a nM
Citation
 Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem 27:1693-1703 (2019) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:
63227.28
Organism:
Mus musculus (mouse)
Description:
Mouse brain membranes were used in the assay.
Residue:
579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
  
Inhibitor
Name:
BDBM50052767
Synonyms:
CHEMBL3318612
Type:
Small organic molecule
Emp. Form.:
C23H26N4O2
Mol. Mass.:
390.4781
SMILES:
Cc1cnn(c1)C(=O)N1CCN(Cc2ccc(OCc3ccccc3)cc2)CC1
Structure:
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