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Target
Kappa-type opioid receptor
Ligand
BDBM50506099
Substrate
n/a
Meas. Tech.
ChEMBL_1824938 (CHEMBL4324702)
EC50
11±n/a nM
Citation
 Xiao, L; Wang, Y; Zhang, M; Wu, W; Kong, L; Ma, Y; Xu, X; Liu, X; He, Q; Qian, Y; Sun, H; Wu, H; Lin, C; Huang, H; Ye, R; Jiang, S; Ye, RF; Yuan, C; Fang, S; Xue, D; Yang, X; Chen, H; Zheng, Y; Yu, L; Xie, Q; Zheng, L; Fu, W; Li, W; Qiu, Z; Liu, J; Shao, L Discovery of a Highly Selective and Potent ? Opioid Receptor Agonist from  J Med Chem 62:11054-11070 (2019) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50506099
Synonyms:
CHEMBL4451186
Type:
Small organic molecule
Emp. Form.:
C30H36N2O3
Mol. Mass.:
472.6184
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@H](C1)c1ccc(N)cc1)ccc3OC |r,THB:10:9:17:4.5.6|
Structure:
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