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Target
Neutrophil elastase
Ligand
BDBM50058481
Substrate
n/a
Meas. Tech.
ChEMBL_63796 (CHEMBL679049)
IC50
36±n/a nM
Citation
 Portevin, B; Lonchampt, M; Canet, E; De Nanteuil, G Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives. J Med Chem 40:1906-18 (1997) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50058481
Synonyms:
(2R,3aR,7aR)-1-(2-{4-[(E)-3-(3,5-Di-tert-butyl-4-ethoxymethoxy-phenyl)-acryloylsulfamoyl]-benzoylamino}-3-methyl-butyryl)-octahydro-indole-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL292348
Type:
Small organic molecule
Emp. Form.:
C47H65F3N4O9S
Mol. Mass.:
919.101
SMILES:
CCOCOc1c(cc(\C=C\C(=O)NS(=O)(=O)c2ccc(cc2)C(=O)NC(C(C)C)C(=O)N2[C@@H]3CCCC[C@@H]3C[C@@H]2C(=O)NC(C(C)C)C(=O)C(F)(F)F)cc1C(C)(C)C)C(C)(C)C
Structure:
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