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Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligand
BDBM50506980
Substrate
n/a
Meas. Tech.
ChEMBL_1828851 (CHEMBL4328725)
Ki
73±n/a nM
Citation
 Najjar, A; Platzer, C; Luft, A; Aßmann, CA; Elghazawy, NH; Erdmann, F; Sippl, W; Schmidt, M Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1. Eur J Med Chem 161:479-492 (2019) [PubMed]  Article 
Target
Name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:
MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:
PROTEIN
Mol. Mass.:
54523.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587209
Residue:
499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
  
Inhibitor
Name:
BDBM50506980
Synonyms:
CHEMBL4583196
Type:
Small organic molecule
Emp. Form.:
C21H24ClN7O2S
Mol. Mass.:
473.979
SMILES:
Cc1nc(Nc2ncc(s2)C(=O)Nc2ccccc2Cl)cc(n1)N1CCN(CCO)CC1
Structure:
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