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Target
Falcipain 2
Ligand
BDBM50059577
Substrate
n/a
Meas. Tech.
ChEMBL_69691 (CHEMBL682027)
IC50
30000±n/a nM
Citation
 Domínguez, JN; López, S; Charris, J; Iarruso, L; Lobo, G; Semenov, A; Olson, JE; Rosenthal, PJ Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. J Med Chem 40:2726-32 (1997) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50059577
Synonyms:
7-Chloro-2-(2,4-dichloro-phenyl)-5,5-dioxo-2,3,5,10-tetrahydro-1H-5lambda*6*-phenothiazin-4-one | CHEMBL93846
Type:
Small organic molecule
Emp. Form.:
C18H12Cl3NO3S
Mol. Mass.:
428.717
SMILES:
Clc1ccc(C2CC(=O)C3C(C2)=Nc2ccc(Cl)cc2S3(=O)=O)c(Cl)c1 |c:12|
Structure:
Search PDB for entries with ligand similarity: