Reaction Details Report a problem with these data
Target
Falcipain 2
Ligand
BDBM50059559
Substrate
n/a
Meas. Tech.
ChEMBL_69691 (CHEMBL682027)
IC50
4000±n/a nM
Citation
 Domínguez, JN; López, S; Charris, J; Iarruso, L; Lobo, G; Semenov, A; Olson, JE; Rosenthal, PJ Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. J Med Chem 40:2726-32 (1997) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50059559
Synonyms:
7-Chloro-2-(4-chloro-phenyl)-2,3-dihydro-1H,10H-phenothiazin-4-one | CHEMBL91050
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2NOS
Mol. Mass.:
362.273
SMILES:
Clc1ccc(cc1)C1CC(=O)C2Sc3cc(Cl)ccc3N=C2C1 |c:22|
Structure:
Search PDB for entries with ligand similarity: