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Target
Falcipain 2
Ligand
BDBM50059567
Substrate
n/a
Meas. Tech.
ChEMBL_69691 (CHEMBL682027)
IC50
50000±n/a nM
Citation
 Domínguez, JN; López, S; Charris, J; Iarruso, L; Lobo, G; Semenov, A; Olson, JE; Rosenthal, PJ Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. J Med Chem 40:2726-32 (1997) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50059567
Synonyms:
7-Chloro-2-(3,4-dimethoxy-phenyl)-5,5-dioxo-2,3,5,10-tetrahydro-1H-5lambda*6*-phenothiazin-4-one | CHEMBL93694
Type:
Small organic molecule
Emp. Form.:
C20H18ClNO5S
Mol. Mass.:
419.879
SMILES:
COc1ccc(cc1OC)C1CC(=O)C2C(C1)=Nc1ccc(Cl)cc1S2(=O)=O |c:18|
Structure:
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