Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50507373
Substrate
n/a
Meas. Tech.
ChEMBL_1829816 (CHEMBL4329690)
EC50
>50000±n/a nM
Citation
 Li, J; Kennedy, LJ; Walker, SJ; Wang, H; Li, JJ; Hong, Z; O'Connor, SP; Ye, XY; Chen, S; Wu, S; Yoon, DS; Nayeem, A; Camac, DM; Ramamurthy, V; Morin, PE; Sheriff, S; Wang, M; Harper, TW; Golla, R; Seethala, R; Harrity, T; Ponticiello, RP; Morgan, NN; Taylor, JR; Zebo, R; Maxwell, B; Moulin, F; Gordon, DA; Robl, JA Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD-1). ACS Med Chem Lett 9:1170-1174 (2018) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50507373
Synonyms:
CHEMBL4472732
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O2
Mol. Mass.:
355.818
SMILES:
CC(C)(C(O)=O)c1cccn2c(nnc12)C1(CC1)c1ccc(Cl)cc1
Structure:
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