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Target
Pirin
Ligand
BDBM50234074
Substrate
n/a
Meas. Tech.
ChEMBL_1830006 (CHEMBL4329880)
IC50
44±n/a nM
Citation
 Meyers, J; Chessum, NEA; Ali, S; Mok, NY; Wilding, B; Pasqua, AE; Rowlands, M; Tucker, MJ; Evans, LE; Rye, CS; O'Fee, L; Le Bihan, YV; Burke, R; Carter, M; Workman, P; Blagg, J; Brown, N; van Montfort, RLM; Jones, K; Cheeseman, MD Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett 9:1199-1204 (2018) [PubMed]  Article 
Target
Name:
Pirin
Synonyms:
PIR | PIR_HUMAN | Probable quercetin 2,3-dioxygenase PIR | Probable quercetinase
Type:
PROTEIN
Mol. Mass.:
32115.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811273
Residue:
290
Sequence:
MGSSKKVTLSVLSREQSEGVGARVRRSIGRPELKNLDPFLLFDEFKGGRPGGFPDHPHRGFETVSYLLEGGSMAHEDFCGHTGKMNPGDLQWMTAGRGILHAEMPCSEEPAHGLQLWVNLRSSEKMVEPQYQELKSEEIPKPSKDGVTVAVISGEALGIKSKVYTRTPTLYLDFKLDPGAKHSQPIPKGWTSFIYTISGDVYIGPDDAQQKIEPHHTAVLGEGDSVQVENKDPKRSHFVLIAGEPLREPVIQHGPFVMNTNEEISQAILDFRNAKNGFERAKTWKSKIGN
  
Inhibitor
Name:
BDBM50234074
Synonyms:
CHEMBL4070633 | US9701664, Example 39
Type:
Small organic molecule
Emp. Form.:
C27H23N3O4
Mol. Mass.:
453.4892
SMILES:
Cc1ccc2cc(ccc2n1)C(=O)Nc1cc(NC(=O)c2ccc3OCCOc3c2)ccc1C
Structure:
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