Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM18512
Substrate
n/a
Meas. Tech.
ChEMBL_1830100 (CHEMBL4329974)
Ki
28±n/a nM
Citation
Tarnchompoo, B; Chitnumsub, P; Jaruwat, A; Shaw, PJ; Vanichtanankul, J; Poen, S; Rattanajak, R; Wongsombat, C; Tonsomboon, A; Decharuangsilp, S; Anukunwithaya, T; Arwon, U; Kamchonwongpaisan, S; Yuthavong, Y Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance. ACS Med Chem Lett 9:1235-1240 (2018) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND