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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50060435
Substrate
n/a
Meas. Tech.
ChEMBL_1611 (CHEMBL616636)
IC50
430±n/a nM
Citation
 MacLeod, AM; Street, LJ; Reeve, AJ; Jelley, RA; Sternfeld, F; Beer, MS; Stanton, JA; Watt, AP; Rathbone, D; Matassa, VG Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. J Med Chem 40:3501-3 (1997) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50060435
Synonyms:
3-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[1,2,4]triazol-4-yl-1H-indole | CHEMBL117249
Type:
Small organic molecule
Emp. Form.:
C18H24N6
Mol. Mass.:
324.4234
SMILES:
CN1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Structure:
Search PDB for entries with ligand similarity: