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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50508042
Substrate
n/a
Meas. Tech.
ChEMBL_1832059 (CHEMBL4332067)
EC50
5.0±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure. Bioorg Med Chem Lett 29:373-379 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50508042
Synonyms:
CHEMBL4582928
Type:
Small organic molecule
Emp. Form.:
C24H30FN3O4S
Mol. Mass.:
475.576
SMILES:
CC1(C)C[C@@]2(CO1)CC[C@@H](CC2)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O |r,wU:4.4,9.13,(26.97,-16.97,;25.49,-17.37,;26.58,-18.46,;24.47,-18.52,;23.06,-17.9,;23.21,-16.37,;24.71,-16.05,;21.72,-17.13,;20.38,-17.9,;20.39,-19.44,;21.72,-20.21,;23.05,-19.45,;19.06,-20.21,;17.72,-19.44,;17.72,-17.9,;16.37,-17.13,;15.05,-17.9,;15.06,-19.44,;13.73,-20.21,;14.28,-21.86,;15.97,-21.87,;16.39,-20.21,;12.39,-19.44,;12.39,-17.89,;11.05,-17.13,;9.72,-17.9,;9.72,-19.45,;11.05,-20.22,;11.05,-21.76,;8.39,-17.13,;7.05,-17.9,;7.61,-15.79,;9.16,-15.79,)|
Structure:
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